ABOUT PONICIDIN

TAK-243 preferentially bound to UBA1 above the connected E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased levels of ubiquitylated proteins, greater markers of proteotoxic tension and DNA harm tension. In vivo, TAK-243 decreased leukemic load and focused leukemic stem cells without having evidence of tox